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Découverte -
Cirrhose : un test pour mieux prédire l’évolution des malades

Les maladies chroniques du foie peuvent évoluer vers une fibrose fibrose Remplacement de tissus sains par des tissus cicatriciels. de l’organe puis une cirrhose, jusqu’à nécessiter une transplantation hépatique. Comment prédire l’évolution de l’état des patients atteints de cirrhose pour mieux gérer les urgences ? C’est à cette question que répondent les travaux d’une équipe Inserm du Centre de recherche cardiovasculaire de Paris, en collaboration avec le service d’hépatologie de l’hôpital Beaujon (AP-HP). Ces chercheurs ont en effet montré que les microvésicules libérées dans le sang par les...

Discovery -
Enable Injections enFuse Makes Self-Administered Biologics Less Intimidating

While most of us would prefer to take our medications orally, many kinds of drugs, such as biologics, must be injected. Biologics themselves, however, are often difficult to inject, as the effective dose is often large and the biologic is often viscous, requiring significant force and injection time to administer, meaning more discomfort. Patients needing these complex molecules typically must visit a clinic to have these biologics administered intravenously by a clinician. On our recent visit to the Cincinnati area, we visited a startup called Enable Injections that has developed a device...

France -
Comptes de la sécurité sociale : un déficit 2017 de l'ensemble des organismes de sécurité sociale en recul de 2,1 milliard

Le déficit de l'ensemble des organismes de sécurité sociale s'est réduit de 2,1 Md€ par rapport à 2016. Le solde 2017 des organismes de sécurité sociale s'établit à - 5,2 Md€ contre ­ 7,3 Md€ en 2016. La prise en compte des autres régimes augmente légèrement le déficit (+0,1 Md€) par rapport à celui du régime général (y compris régimes alignés) et du FSV. Les excédents du régime des professions libérales (CNAVPL) et des collectivités locales (CNRACL), en réduction par rapport à 2016, ne suffisent plus à compenser les déficits des autres régimes. La branche vieillesse contribue le plus à cette...

France -
Vers la création d'une carte Vitale dématérialisée

Un projet de décret soumis à concertation et dont APMnews (site du groupe d'information APM International, dont fait partie TICsanté) a eu copie vise à expérimenter pour un an le déploiement d'une carte Vitale dématérialisée ou "eCarte d'assurance maladie". La convention d'objectifs et de gestion (COG) de la Caisse nationale de l'assurance maladie (Cnam) pour 2018-2022 prévoit l'expérimentation d'un tel dispositif à partir de 2018, et sa généralisation dès 2019...

Study -
Women with pregnancy-related diabetes may be at risk for chronic kidney disease

Gestational diabetes may predispose women to early-stage kidney damage, a precursor to chronic kidney disease, according to a study by researchers at the National Institutes of Health and other institutions. The study appears in Diabetes Care . Gestational diabetes occurs only in pregnancy and results when the level of blood sugar is too high. The condition increases the risk for preterm birth and cesarean delivery, among other complications. Other forms of diabetes that occur outside of pregnancy are known to increase the risk for chronic kidney disease , in which the kidneys have difficulty...

Study -
International study suggests combination therapy may prevent stroke in certain people

NIH-funded trial finds lower rate of secondary stroke but small risk of bleeding. Results from an international clinical trial of more than 4880 participants, published in the New England Journal of Medicine, show that combining clopidogrel and aspirin following a small stroke or experiencing minor stroke symptoms decreases risk of a new stroke, heart attack or other ischemic event within 90 days. The combination therapy was also associated with an increase in major bleeding, although many of those episodes were non-fatal and did not occur in the brain. The results were presented at the 4 th...

Study -
Male depression may lower pregnancy chances among infertile couples

Study also links women’s use of non-SSRI antidepressants to early pregnancy loss. Among couples being treated for infertility, depression in the male partner was linked to lower pregnancy chances, while depression in the female partner was not found to influence the rate of live birth, according to a study funded by the National Institutes of Health. The study, which appears in Fertility and Sterility , also linked a class of antidepressants known as non-selective serotonin reuptake inhibitors (non-SSRIs) to a higher risk of early pregnancy loss among females being treated for infertility...

Etude -
Mélanome : une nouvelle cible thérapeutique pour les formes résistantes

Les cellules de mélanome mélanome Tumeur maligne de la peau. sont très "plastiques" : elles s’adaptent à leur environnement et, ainsi, peuvent devenir résistantes aux traitements. Une équipe Inserm a découvert un élément clé de cette plasticité. Il s’agit de la protéine NAMPT, qui constitue dès lors une nouvelle cible thérapeutique… Dans 50 à 70% des cas, un mélanome est associé à une mutation affectant le gène BRAF, responsable de la prolifération cellulaire. Cette découverte a permis la mise au point de traitements ciblés, qui bloquent spécifiquement l’enzyme kinase kinase Enzyme capable de...

Study -
Proposed Guidelines Could Leave Some PTSD Patients in the Dark

A new study shows proposed changes in the International Classification of Diseases (ICD) guidelines could lead to a reduction in the diagnosis of PTSD patients. Researchers from the New York University (NYU) School of Medicine said fewer patients would be diagnosed with post-traumatic stress disorder (PTSD) under proposed changes to diagnostic criteria for the disease. The researchers conducted a study of how the guidelines could impact PTSD diagnosis and those findings were published Monday in the journal Psychological Medicine . The guidelines in question are the International...

Discovery -
Two New Drug Classes Tied to Better Survival in Type 2 Diabetes

Patients with type 2 diabetes who did not achieve adequate glycemic control with metformin had improved survival during follow-up if they received add-on therapy with a sodium-glucose cotransporter 2 (SGLT-2) inhibitor or a glucagon-like peptide 1 (GLP-1) agonist rather than a dipeptidyl peptidase-4 (DPP-4) inhibitor or control (placebo or no treatment), in a network meta-analysis that indirectly compared these three drug classes. Rates of heart failure and myocardial infarction (MI) were also lower in patients who received SGLT-2 inhibitors rather than controls. But GLP-1 agonists were...

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