Europe – EC green-lights MSD’s Keytruda combo for lung cancer

The European Commission has approved MSD’s Keytruda for use in combination with Eli Lilly’s Alimta and platinum-based chemotherapy for the first-line treatment of some advanced lung cancers.

Specifically, the decision allows use of the combination in patients with metastatic non-squamous non-small cell lung cancer (NSCLC) who have no EGFR or ALK positive mutations.

Keytruda (pembrolizumab) is the first immunotherapy to be approved by the EC for treatment of NSCLC in combination with chemotherapy, on the back of data from the KEYNOTE-189 trial, which showed that the combination cut the risk of death by more than 50% compared to Alimta (pemetrexed) and platinum-based chemotherapy alone.

A reduction in the risk of disease progression or death of 48% was also observed with pembrolizumab in combination with pemetrexed and platinum-based chemotherapy…