Europe – NICE nod for Novartis’ targeted skin cancer combo

The National Institute for Health and Care Excellence has backed NHS funding for Novartis’ oral targeted adjuvant combination therapy Tafinlar and Mekinist, offering new hope to patients with a specific type of skin cancer.

Final draft guidelines are recommending the combination for use in patients with stage III BRAF V600 mutation-positive melanoma who have disease that has spread to lymph vessels, or lymph glands close to the melanoma and who have already had surgery to remove the tumour and associated lymph glands.

To date, this patient group had almost no other treatment options following surgery, aside from radiotherapy in some circumstances, but in over half of cases the cancer recurs, increasing the risk of progressing to the most advanced and incurable stage of the disease.

The aim of Novartis’ adjuvant therapy is to remove any residual cancer left behind to prevent recurrence, and clinical trial results show that patients taking Tafinlar (dabrafenib) plus Mekinst (trametinib) had higher rates of relapse-free survival (88% at 1 year, 67% at 2 years, and 58% at 3 years) compared with patients taking the placebo (56% at 1 year, 44% at 2 years, and 39% at 3 years)…