International – Impurities : Guideline for Residual Solvents Q3C(R8)

Introduction
2-Methyltetrahydrofuran (2-MTHF, synonyms: 2-Methyloxolane, Tetrahydrosylvan; Tetrahydro 2-methylfuran; CAS Number 96-47-9) is a colourless, volatile liquid with ether-like odour. 2-MTHF is an organic solvent usually synthesized as a racemic mixture consisting of two enantiomeric forms ((S)+ and (R)-). Solubility in water is limited and decreases with increasing temperature. It has a vapour pressure of 136 mbar (20°C) (1)…