The data shows that a booster dose of both Omicron-adapted vaccines gave a considerably higher immune response against Omicron BA.1, compared to Pfizer/BioNTech’s current COVID-19 vaccine.
The phase 2/3 trial involved 1,234 participants aged 56 and older. One month after receiving a booster dose, the Omicron-adapted monovalent candidates significantly increased protection against Omicron BA.1, showing a 13.5 and 19.6-fold increase above pre-booster dose levels.
One vaccine is monovalent and the other is bivalent, made up from a combination of the Pfizer/BioNTech COVID-19 vaccine and a vaccine candidate designed to target the spike protein of the Omicron BA.1 variant.
