The researchers created a protein map for 949 cancer cell lines across over 40 cancer types, which were tested with 650 different treatments. Advanced computational methods were then used to predict the response of cancer cells to treatment, with the results also pinpointing vulnerabilities in cancer cells that provide opportunities for developing new treatments.
The paper, published in Cancer Cell, ‘lays the foundation’ for ongoing efforts to predict the response of an individual cancer to the response of an individual cancer to drugs based on the proteins the cancer contains.
Mathew Garnett, a senior author of the study from the Wellcome Sanger Institute, said: « In addition to revealing new insights about the biology of cancer, this study is also helping to fulfil the mission of my team to generate reference datasets for widespread use in the international cancer research community.”…
