UK – AbbVie’s Venclyxto hit with NICE rejection

Draft guidelines do not recommend NHS use of AbbVie’s Venclyxto for treating relapsed or refractory chronic lymphocytic leukaemia (CLL).

The National Institute for Health and Care Excellence said there were uncertainties with both the clinical evidence and the economic modeling provided.

Clinical trial evidence does suggest that Venclyxto (venetoclax) plus rituximab boosts progression free survival compared with bendamustine plus rituximab, but the latter combination is now “rarely used”, it noted.

Also, indirect comparisons of the regimen with the current standard of care, ibrutinib (AbbVie/Johnson & Johnson’s Imbruvica), “have limitations, so no firm conclusions can be drawn about the size of the benefit for venetoclax plus rituximab”.

Therefore, it was concluded that Venclyxto could not be recommended either for routine NHS use or for inclusion in the Cancer Drugs Fund…