UK – NICE approves Lynparza plus Avastin via Cancer Drugs Fund

The National Institute for Health and Care Excellence (NICE) has recommended AstraZeneca/MSD’s Lynparza combined with Roche’s Avastin for certain patients with ovarian cancer via the Cancer Drugs Fund (CDF).

Through the CDF, Lynparza (olaparib) with Avastin (bevacizumab) can now be used as a maintenance treatment for patients with homologous recombination deficiency (HRD) positive advanced ovarian, fallopian tube and peritoneal cancer, following complete or partial response to first-line platinum-based chemotherapy and Avastin.

In the Phase III PAOLA-1 trial, Lynparza in combination with Avastin reduced the risk of disease progression or death by 67% in these patients, compared to treatment with Avastin alone…