UK – NICE backing for Takeda’s Adcetris for rare lymphoma

Takeda's Adcetris (brentuximab vedotin) has won the backing of the National Institute for Health and Care Excellence (NICE) as a treatment for untreated systemic anaplastic large cell lymphoma (sALCL), a rare type of lymphoma.

The decision allows NHS funding for the drug alongside cyclophosphamide, doxorubicin and prednisone (CHP), giving patients access to the first new front-line treatment option for the condition in several decades.

To date, frontline treatment for newly diagnosed sALCL patients has typically been multi-agent chemotherapy, such as CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), which is generally associated with poor outcomes, with many patients failing to achieve long-term survival, the firm notes.

In the clinical trial ECHELON-2, Adcetris plus CHP demonstrated superior progression-free survival and overall survival versus CHOP in the sALCL patient population, which corresponded to a 41% reduction in the risk of a progression event and a 46% reduction in the risk of death…