UK – NICE nod for Blincyto

The National Institute for Health and Care Excellence (NICE) has announced the recommendation of Amgen’s Blincyto (blinatumomab) for treating acute lymphoblastic leukaemia (ALL). The indication is for patients in first complete remission with minimal residual disease (MRD) activity of at least 0.1%.

This decision to recommend the drug as a cost-effective use of NHS resources follows the submission of new evidence from the company during consultation on earlier draft recommendations.

Amgen has a confidential commercial arrangement which will make the drug available to the NHS with a discount.

The use of Blincyto compared to continued chemotherapy may reduce MRD and help increase the time people have without their disease relapsing. People with lower MRD levels have a higher chance of their disease being cured after stem cell transplantation.

Administration is by continuous intravenous infusion delivered at a constant rate using an infusion pump. A single cycle of the treatment comprises continuous intravenous infusion at a dose of 28 micrograms/day for 28 days, followed by a 14‑day treatment-free interval…