UK – Polivy struck by NICE ‘no’

The National Institute for Health and Care Excellence (NICE) has announced that it does not recommend Polivy (polatuzumab), Roche’s treatment for adults with diffuse large B-cell lymphoma (DLBCL).

The organisation has published a draft guidance rejecting the drug in combination with MabThera (rituximab) and bendamustine, for patients whose disease has relapsed or not responded to primary treatment and who cannot have a haematopoietic stem cell transplant.

The decision was made despite clinical trial evidence showing that the cancer became undetectable in around 40% of patients treated with Polivy, MabThera and bendamustine, compared with around 18% of patients treated with MabThera and bendamustine alone…