IgA neuropathy, also known as Berger’s disease, is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) builds up in your kidneys.
Sparsentan was approved under the International Recognition Procedure (IRP), following route B.
The active ingredient in Filspari, sparsentan, works by blocking the receptors for two hormones called endothelin and angiotensin. Endothelin and angiotensin play a role in regulating processes in the kidney such as inflammation that lead to progression of kidney damage.
By blocking these receptors, Filspari lowers the amount of protein that leaks into the urine, and thereby helps to slow down progression of the disease…
