USA – mRNA technology for universal flu vaccine shows early promise in US study

A new mRNA vaccine targeting all 20 known strains of influenza has shown early promise in a new study by researchers at the University of Pennsylvania's Perelman School of Medicine, potentially paving the way to a universal flu vaccine that might help prevent future pandemics.

The World Health Organization cites vaccination as the current principal means of reducing or counteracting influenza mortality and morbidity burden, but the constantly evolving nature of influenza viruses requires continuous global monitoring and frequent reformulation of influenza vaccines.

Each year, even when currently available vaccine strains match circulating influenza virus strains well, those vaccines typically offer only around 40% to 60% protection, with even lower protection in years with poor matching of strains.

A universal flu vaccine would eliminate the guesswork that goes into identifying and developing viral composition of influenza vaccines each year, allowing the immune system to recognise any flu virus it might encounter in the future…